The NEOS Server offers the ECM solver to optimize enzyme profiles and corresponding metabolite profiles that realize a desired flux at minimum cost. The required data must be specified in a zip file. The Enzyme Cost Minimization case study on the NEOS Guide describes the problem in more detail. The ECM solver was developed by Meike Wortel and Michael Ferris.
The user must provide the required data in a zip file and select a nonlinear programming solver.