The NEOS Server offers the ECM solver to optimize enzyme profiles and corresponding metabolite profiles that realize a desired flux at minimum cost. The Enzyme Cost Minimization case study on the NEOS Guide describes the problem in more detail.

The ECM solver was developed by Meike Wortel and Michael Ferris.

Using the NEOS Server for ECM/zip

The user must provide the required data in a zip file and select a nonlinear programming solver.

Web Submission Form
Input Zip File
Enter the location of the zip file containing all of the data in standard format.
Nonlinear Solver
Select an NLP solver.

Additional Settings

E-Mail address:
Please do not click the 'Submit to NEOS' button more than once.