The NEOS Server offers the ECM solver to optimize enzyme profiles and
corresponding metabolite profiles that realize a desired flux at
minimum cost. The Enzyme
Cost Minimization case study on the NEOS Guide describes the
problem in more detail.
The ECM solver was developed by Meike Wortel and Michael Ferris.
The user must provide the required data files in the CSV format
specified below and select a nonlinear programming solver.