The NEOS Server offers the ECM solver to optimize enzyme profiles and corresponding metabolite profiles that realize a desired flux at minimum cost. The
required data must be specified in a set of required files in CSV format.
The Enzyme Cost Minimization case study on the NEOS Guide describes the problem in more
detail. The ECM solver was developed by Meike Wortel and Michael Ferris.
The user must provide the required data files in the CSV format specified below and select a nonlinear programming solver.